Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder, affecting 10–18% of women of reproductive age. Based on the Rotterdam consensus, PCOS is diagnosed by at least two of the following three criteria: oligo- or anovulation, hyperandrogenism, and polycystic ovaries on ultrasound. Thus, four different phenotypes can be recognized. In addition, PCOS is also a metabolic disorder since many affected women present with obesity, insulin resistance and associa...

The prenatally androgenised sheep, like the Rhesus monkey, is an informative model for polycystic ovary syndrome (PCOS). We have recently demonstrated that AMH protein is reduced in preantral follicles of PCOS ovaries (Stubbs et al, Endocrine Abstracts 2004, 7 P186 ). We hypothesized that reduced expression of AMH is an effect of androgen excess. The aim of this study was to examine AMH immunostaining in ovaries from prenatally androgen-treated and control ewes. Ovaries were t...